October 19, 2010

Not all fat is equal

Nature Genetics is about to publish research on the genetics of fat that included a quarter of a million people. The international consortium uncovered 18 new gene sites associated with obesity, adding them to a list of 20 already identified genes. 13 new sites that affect fat distribution were also discovered.

If you just so happen to carry the majority of the 38 variants you will, on average, be 15-20 pounds heavier. This isn't obesity though, just a heavier set person. An obese individual may carry the majority of variants, but almost always there are environmental factors (like poor diet choices) contributing to the weight.

The 13 gene variants for fat distribution control whether you'll be an apple shape (all in your tummy) or a pear shape (hips, butt, and thighs).

If you're an apple shape you'll have more complications associated with your fat, such as type II diabetes, heart disease, and cancer. ACS's Journal of Proteome Research has recently published research that the apron of fat we all have over our lower tummy-greater omentum- isn't just some idle storage unit for excess calories. Apparently, these fat cells secrete hormones and other substances just like our other organs. Scientists were surprised to discover fat cells secreting hormones like leptin, which controls appetite, and adiponectin, which makes the body more sensitive to insulin and and controls blood sugar levels. These are just 2 of the 80 proteins they found in fat cells. Of course, more research is needed to figure out what all these proteins are up to.

As a fellow pear shape, I must admit the lower risk of disease is no consolation when I get dressed everyday. But as a woman, I just have to accept my body puts fat there for a specific reason; baby, spawn, whatever you'd like to call it. If your a women, 7 of the 13 fat distributing gene variants have a much stronger effect on you than men.

Genes don't have the final say in someone being overweight. That excuse will only work for a small, small percent of the population. For the majority of us, it's a combo of our genes and diet. Since we can't modify our genes yet, that only leaves one other option.

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